Messianic freedom and the secular academy: educating the affections in a technological culture

Paper presented at the conf Faith, freedom and the academy: the idea of the university in the 21st century, Univ of Prince Edward Island, O 1-3 2004

Characterizing Strategic Cascades on Networks

Transmission of disease, spread of information and rumors, adoption of new products, and many other network phenomena can be fruitfully modeled as cascading processes, where actions chosen by nodes influence the subsequent behavior of neighbors in the network graph. Current literature on cascades tends to assume nodes choose myopically based on the state of choices already taken by other nodes. We examine the possibility of strategic choice, where agents representing nodes anticipate the choices of others who have not yet decided, and take into account their own influence on such choices. Our study employs the framework of Chierichetti et al. [2012], who (under assumption of myopic node behavior) investigate the scheduling of node decisions to promote cascades of product adoptions preferred by the scheduler. We show that when nodes behave strategically, outcomes can be extremely different. We exhibit cases where in the strategic setting 100% of agents adopt, but in the myopic setting only an arbitrarily small epsilon % do. Conversely, we present cases where in the strategic setting 0% of agents adopt, but in the myopic setting (100-epsilon)% do, for any constant epsilon > 0. Additionally, we prove some properties of cascade processes with strategic agents, both in general and for particular classes of graphs.Comment: To appear in EC 201

No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms

G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein, were found in GH-secreting pituitary tumors. These mutations resulted in constitutively activated Gs alpha and high intracellular cAMP levels. In addition, point mutations at similar codons of a different G-protein, G(i) alpha 2, were reported in adrenocortical neoplasms, suggesting a potential role of this isoform in the genesis of these tumors. We reevaluated the frequency of constitutively activating point mutations in the alpha- chain of the stimulatory (Gs alpha) and inhibitory (G(i) alpha 2) G- proteins in human adrenocortical tumors. Seven adrenocortical carcinomas, 2 human adrenocortical tumor cell lines, and 11 adrenocortical adenomas were studied. Genomic DNA was purified from either frozen tumor tissue or paraffin-embedded sections. Using specific primers and the polymerase chain reaction, DNA fragments surrounding codons 201 and 227 (Gs alpha) and 179 and 205 (G(i) alpha 2) were amplified and visualized on a 2% agarose gel. In a second asymmetric polymerase chain reaction, using nested primers, single stranded DNA was generated using 1-10 microL of the initial amplification mixture and directly sequenced using the dideoxy chain termination method of Sanger. We found no mutations at codons 201, 227 and 179, 205 of Gs alpha and G(i) alpha 2, respectively, in the tumors studied. We conclude that previously identified oncogenic point mutations in the stimulatory and inhibitory alpha-chain of G-proteins do not appear to be present at high frequency in adrenal neoplasms. Thus, the mechanism(s) of tumorigenesis in these tumors is different from that in GH-secreting adenomas and may involve oncogenic mutations of other cell constituents

Quantum Enhanced Magnetometer with Low-Frequency Squeezing

We report the demonstration of a magnetometer with noise-floor reduction below the shot-noise level. This magnetometer, based on a nonlinear magneto-optical rotation effect, is enhanced by the injection of a squeezed vacuum state into its input. The noise spectrum shows squeezed noise reduction of about 2 dB spanning from close to 100 Hz to several megahertz. We also report on the observation of two different regimes of operation of such a magnetometer: one in which the detection noise is limited by the quantum noise of the light probe only, and one in which we see additional noise originating from laser noise which is rotated into the vacuum polarization